The Open Philanthropy Project recommended a multi-year grant of $6,421,402 to Arizona State University to support a canine clinical trial assessing the effectiveness of a multivalent, preventative cancer vaccine. This grant falls within Open Philanthropy's work on scientific research, and was identified through its 2016 NIH Transformative Research Award RFP.
The trial will test the cancer-prevention efficacy of a multi-valent frameshift peptide (FSP) vaccine, developed by Dr. Stephen Albert Johnston, in healthy, middle-aged pet dogs.{footnote_1} The trial will be conducted under the direction of Dr. Douglas Thamm, Director of Clinical Research at the Flint Animal Cancer Center at Colorado State University.{footnote_2} The dogs will live their normal lives at home and receive biannual exams with a complete clinical pathology workup, and each owner whose dog develops cancer during the trial will be given a credit toward medical expenses. Cancer will not be induced in dogs in the study, which will only test the effectiveness of the vaccine against naturally occurring cancer.
If successful, this trial would provide strong support for the concept of employing FSP vaccines to prevent cancer in the early stages, possibly lead to a canine cancer vaccine, and could eventually justify human clinical trials for both treatment and prevention. The funding will be split into an initial payment to support trial set-up and recruitment, and if successful, additional payments will be released to fund all aspects of the trial including examination, vaccination, and follow up over five to seven years.