The Open Philanthropy Project recommended a grant of $180,000 to the Yale University School of Medicine to support research on the modification of vascular permeability by monoclonal antibodies against key regulatory proteins. Increased permeability might allow medicines to cross the blood-brain barrier and could accelerate the development of new therapies for neurogenerative diseases such as Alzheimer’s Disease, while decreased permeability could be useful in treating conditions such as swelling in stroke victims and sepsis.
This grant falls within Open Philanthropy's work on scientific research, and specifically within its interest in advancing human health and wellbeing.